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doi: 10.4161/auto.20764 Summary Keywords reticulocytes, pyruvate kinase deficiency, ferroptosis, mitophagy, GPX4 Citation van Vuren AJ, van Beers EJ and van Wijk R (2021) A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency

566,567,568 For example, shRNA-mediated knockdown of XBP1 in fibrosarcoma cells or expression of dominant-negative IRE1 in glioma cells significantly inhibited tumor growth and angiogenesis

2.2 Pathogenesis and pathophysiology of hyperuricemia Hyperuricemia is the precursor state to gout, but its pathophysiological impact extends far beyond the joints, involving multiple systems, including cardiovascular diseases, chronic kidney disease, and metabolic disorders (Wang Q

as such, it is sometimes described as a pathobiont [212]

Figures S4 and S5 show networks of routes of administration for secondary outcomes