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Clinical trials, such as the Assessment of the Effects of Efpeglenatide on Cardiovascular and Renal Outcomes (AMPLITUDE-O) trial, have demonstrated that GLP-1 RAs reduce the incidence of macroalbuminuria in patients with DKD, independent of glycemic control (101)

Author contributions CS, MA, EA and LB contributed to the design of the study, execution of the experiments and writing of the manuscript

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Mentis N, Vardarli I, Kthe LD et al (2011) GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes

10.1016/j.intimp.2016.01.027 Int

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