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Culture of cancer cells in media mimicking human plasma substantially alters cancer cell metabolism, and, to complicate the matter, nutrient levels in tumor interstitial fluid are different than the nutrient levels found in plasma due to poor vascular architecture and heterogeneity in the tumors [130,131]

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This study will serve as a critical step forward for the application of TAT-CcSOD1 as a potential protective/therapeutic agent against oxidative stress-related conditions in the future