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Metformin, through the induction of 5' AMP-activated protein kinase and subsequently insulin sensitivity, has been widely used as a therapeutic agent in various conditions, including type 2 diabetes mellitus, PCOS and gestational diabetes (Reference Rice, Elia and Jawad42)

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Null-null LDL receptor variants confer higher cardiovascular risk and are less responsive to therapies that depend on LDL receptor activity

HFE can also reverse the TMAO-induced decrease of antioxidant capacity by upregulating the expression of antioxidant enzymes including superoxide dismutase 1 (SOD1), SOD2, glutathione peroxidase 3 (GSH-Px3), and catalase (CAT) in the liver

For example, studies show improvements in running speed, increased maximal oxygen uptake, and decreases in average oxygen consumption, heart rate, and lactic acid