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In other studies, phenytoin was used as a reagent to treat mouse embryos because it causes oxidation of DNA, proteins, and lipids, likely due to increased production of OH radicals (89, 90)

hence, dysregulated drug metabolism as a result of dysfunctional CYP450 enzymes ( An altered microbiome will cause a dysfunctional gut barrier which will affect the first responder to xenobiotics

In neonates where intestinal barrier function is immature, proper availability of nutrients that contribute to the growth of IECs and maturation of the intestinal barrier is critical to support this protective effect

Stress & substances: Manage stress and limit alcohol and smoking, which can accelerate cellular aging