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The biodiversity hypothesis and allergic disease: world allergy organization position statement

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When a GPCR is exposed to its agonist over a period of many minutes to hours or days, the response is significantly reduced and is associated with decreased receptor expression at the plasma membrane, through a related process referred to as downregulation [26]

In case of gene therapy methods, inappropriate gene insertions may occur, leading to malfunctions in the activity of brain structures

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