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Research shows increased GLUT4 expression leading to better glucose clearance, enhanced insulin receptor sensitivity, and normalized metabolic parameters

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10.1186/gb-2009-10-11-r130 156 WuX.ZhangL.MiaoY.YangJ.WangX.WangC.et al (2019)

The consequences of impaired methylation pathways are devastating and result in reduced activity of proteins, reduced production of brain neurotransmitters (seretonin, dopamine, GABA etc), increased inflammation, decreased production of glutathione, alterations in DNA and in cell membrane signaling