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FPN is the only known transmembrane iron exporter in vertebrates, primarily expressed in duodenal enterocytes, hepatocytes, and macrophages, where it plays a crucial role in maintaining cellular and systemic iron homeostasis (39)
34 These effects are achieved by the expression and translocation of apical glucose transporter type 4 (GLUT4) thus increasing glucose uptake and by the inhibition of pro-apoptotic proteins such as Bad, Bax and FOXO family proteins, thereby improving beta cell survival
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BPC 157 nullifies the effect of L-NAME and brings all isoprenaline (+L-NAME) lesions markedly below control values (L-NAME + BPC 157 + isoprenaline

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