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L.et al (2004)

Administration is typically intravenous or intramuscular, which limits its accessibility compared to orally available or injectable peptides, but the clinical evidence supporting its use in serious neurological injury is stronger than that for almost any other peptide in this category

However, there are several side effects caused by NAM, limiting the application of NAM

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Contact your GP if you experience persistent or worsening sleep problems that coincide with starting B12 supplements, particularly if accompanied by other symptoms

Oral KPV places the peptide directly at the intestinal epithelium where inflammation occurs