glutathione arterial plaque Atherosclerosis and Vulnerability Tripeptide DT-109 (Gly-Gly-Leu) attenuates atherosclerosis
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doi: 10.3109/10428199409049647 84 RuvoloPPHuCWQiuYRuvoloVRGoRLHubnerSEet al

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Over time, regular use can result in tolerance, where the initial stimulating effects diminish, requiring higher doses to achieve the same impact