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With the rising incidence of thyroid diseases, the relationship between Hcy and thyroid diseases has attracted widespread attention

Collagen synthesis requires specific amino acids including glycine, proline, and hydroxyproline

The role of microbes in HSCR pathogenesis is intriguing, yet not entirely surprising, since collective efforts have explored and divulged the important contribution of the gut microbiome in fine-tuning the ENS development and homeostasis [65,66,67,68,69,70,71,72], and vice versa [73]

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They are not a quick fix they are a supportive tool within a comprehensive plan

However, the sequential delivery of BMP4 between weeks 4 and 5 followed by Noggin infusion for the following week did not improve remyelination (Sabo et al., 2013), indicating the complexity of growth factor fine tuning and interplay