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Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement J Exp Med 2000 191 : 17451754 Zhong H, Voll RE, Ghosh S

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doi: 10.1172/JCI115204

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This is because benzyl alcohol loses its effectiveness as a preservative with repetitive use and exposure

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