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hypothesis: more daily doses have better efficacy and may have more adverse events

[DOI] [PubMed] [Google Scholar] 36.Di Marzio L, Moretti S, D'Alo S, Zazzeroni F, Marcellini S, Smacchia C, Alesse E, Cifone MG, De Simone C

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For example, studies on the intestinal flora of patients with prehypertension and hypertension have found that the most significant characteristics are the reduction and uneven distribution of microbial diversity and abundance, mainly manifested in the increase of Firmicutes / Bacteroidetes ratio, the decrease of probiotics, and the increase of Prevotella and Klebsiella (26)

for CFS, N = 6 and N = 6, respectively)