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[15] In hepatocytes, compounds undergo enzymatic transformation in two main phases: Phase I reactions (often mediated by cytochrome P450 enzymes) introduce functional groups, and Phase II reactions conjugate these compounds to increase water solubility and facilitate elimination

This therapy is a potential treatment for IPF patients

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Then, each of class III HDACs family members (SIRT1-7) was co-expressed with Flag-GCLC in HEK293T cells

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