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Description
PubMed Dimet-Wiley A, Wu Q, Wiley JT, et al

Bttger F, VallsMart A, Cahn L, Jimenez CR
(2025) 13:e70101
Institutional research settings that track NAD+ levels and methylnicotinamide excretion often find individual dose-response variability of 3040%, meaning the 'right' dose for one subject may be subtherapeutic or excessive for another

Works by inhibiting the enzyme tyrosinase, which is involved in melanin production

Upon activation by ligand binding, AhR is released from the translocation inhibitory complex (formed by chaperone proteins HSP90 and XAP2) which reveals AhRs nuclear localization signal (NLS)