igf 1 lr3 human trial Recombinant IGF-I LR3, ACF IGF-1 LR3, 1 mg at

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had reviewed cases of congenital anomalies after in utero exposure to MTX and proved that some congenital anomalies such as microcephaly, craniosynostosis, tetralogy of Fallot, pulmonary valve atresia, limb reduction defects, and syndactyly were truly part of the fetal methotrexate syndrome [90]

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Both provide potential therapeutic strategies for treating brain injury caused by diabetes, but their clinical application requires further validation

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