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147 DHODH, which is located in the inner mitochondrial membrane, is a critical enzyme responsible for catalyzing the de novo synthesis pathway of pyrimidine nucleotides

doi: 10.1016/j.ejphar.2025.177553, 79

Previous studies have shown hypoperfusion and reduction in the biosynthesis of neurotransmitters such as gamma aminobutyric acid (GABA), glutamate, and aspartate in the frontal, occipital, cingulate, and temporal cortices and basal ganglia

[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Dias S, Pheiffer C, Adam S

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After sequential processing by S1P and S2P, SREBP-2 loses the N-terminal fragment containing the bHLH-Zip region 16