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Researchers Campbell and colleagues demonstrated that lupus was worsened in NOX2-deficient mice ( 3 ROS role in altered apoptosis and as specific biomarkers in SLE ROS generally appear in pathological conditions when scavenged prematurely, and ROS-mediated oxidative damage in SLE results in defective apoptotic control or programmed cell death
Some investigators have proposed that glutathione depletion is a common mechanism underlying multiple age-related diseases, making it a therapeutic target for healthy aging [10][11]

Sur TK, Biswas TK, Ali L, Mukherjee B (2003) Anti-inflammatory and anti-platelet aggregation activity of human placental extract

In conclusion, it is warranted that defining molecular mechanisms will provide better diagnostic information, therapeutic strategies, and prognostic factors in the disease course of RBC-associated disorders, thereby improving the quality of patients lives and the practice of transfusion medicine
