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Type 2 diabetes is associated with increased abundance of Aspergillus, Micrococcus , and Actinomycetes , alongside opportunistic pathogens ( Streptococcus, Clostridium, Escherichia-Shigella, Enterococcus, Klebsiella ) that contribute to metabolic endotoxemia (Zhou et al., 2022)

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Rarely, abnormal bone growth has been reported, but this is generally seen with high doses over extended periods for conditions other than acne

Gepon treatment markedly reduced these elevations, lowering Il1b, Il6, and Nos2 transcripts by approximately threefold each

doi: 10.3109/10715762.2015.1040009