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Long-term deficiency may cause nerve damage and if treatment comes too late, the damage may be irreversible (Rizzo et al., 2016)

This reported association was mediated through adiposity highlighting the potential role of low vitamin B 12 -induced adipocyte dysfunction [17]

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2022;5(1):e2146124

This is based on its ability to counteract ketamine and MK-801, NMDA receptor antagonists that model negative-like schizophrenia symptoms in rodents
