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(15,55) In hepatic steatosis, alterations occur in the fabric structure

Overview of IR The metabolites of chronic overnutrition, such as high glucose and non-esterified fatty acids (NEFAs), interfere with the activation of insulin receptor and its subsequent IRS-1/PI3K/Akt2 pathways, leading to the development of chronic inflammation in adipose tissue and ectopic lipid deposition in the liver and muscles, along with ERS and oxidative stress, etc

Sci., 34 : 208-211

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This warning was grounded on a wide number of studies reviewed in (Micallef et al., 2020b) including a recent report of the French Pharmacovigilance Network conducted in 2019 ( more topical than ever (Micallef et al., 2020b)

Similar findings were previously recorded in the studies of Soyal et al
