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Tirzepatide for T2D obesity SURMOUNT-2, weight -12.8/-14.7% at 10/15 mg, attenuated about 6-7 points vs non-diabetic obesity: Garvey Lancet 2023

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Its mechanism of action involves mimicking natural amylin to regulate appetite control centers, enhancing satiety, slowing gastric emptying, and thereby reducing food intake

TRPV4 mechanosensitive ion channel regulates lipopolysaccharide-stimulated macrophage phagocytosis
