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Researchers suggest that elevated gut pH, gut dysbiosis (i.e., a higher Firmicutes : Bacteroidetes ratio), obesity, or malabsorption might increase fecal SCFA, such as butyrate, which could have potential neurotoxic effects [25, 45, 46]

doi:10.1002/rmb2.12326

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AUA Update Series, Volume 38

PubMed 18644225 Pickart L., Margolina A

2.3 Failure of antioxidant system Nuclear factor erythroid 2-related factor 2 (NRF2) orchestrates cellular antioxidant defense by directly regulating glutathione (GSH) biosynthesis and GPX4 expression through transcriptional control of Glutamate-Cysteine Ligase Catalytic Subunit(GCLC)/ Glutamate-Cysteine Ligase Modifier Subunit(GCLM) and GPX4 (Fan et al., 2024)