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10.1093/brain/awx370 52 BrennerL

Under normal physiological conditions, about 3% of cytosolic glucose is processed via the polyol pathway, however, at higher concentrations of glucose, about 30% of the glucose enters the polyol pathway which makes it important in disposing of the glucose molecules and subsequent conversion to sorbitol [128]

Importantly, alterations in DA synthesis capacity in UHR subjects progress over time and are greater in subjects who transition to psychosis relative to those who do not [67]

doi: 10.1016/B978-0-12-801238-3.64098-9 111 MartnR.MiquelS.UlmerJ.KechaouN.LangellaP.Bermdez-HumarnL

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The treatment was well tolerated with no adverse events and no changes in vital signs, electrocardiograms, or laboratory markers assessing cardiac, liver, kidney, thyroid, or metabolic function