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Candidate genes within these intervals include transcription factor families (MADS-box, bHLH, NAC, and MYB), energy-metabolism enzymes such as malate dehydrogenase, and cytoskeletal components, illustrating how regulatory and metabolic pathways converge during stress adaptation

Similarly, to active MS lesions, in active chronic lesions, mainly in the progressive phase of MS, microglial cells continue to express a reactive profile, but with a notable hallmark of phagocyted iron (140)

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