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Before any scientific compound can be considered safe and effective for clinical use, it typically requires multiple phases of well-designed human clinical trials that evaluate dosage, safety, efficacy, long-term outcomes, and reproducibility

Patients who experience a persistent sensation of tightness at the oral commissure and who present with distortion or retraction of the oral commissure, difficulty controlling a food bolus with chewing or frequent biting of the cheek during chewing, may be considered optimal candidates for botulinum toxin injection into this muscle

References Rajkanna, J., Tariq, S

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