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Signal Transduction and Targeted Therapy 2022 , 7 (1) Feng Pan, Yue-jin Li, Ying Lu

It is an important concept in pharmacology, as it helps to determine the dosage and frequency of drug administration

doi: 10.1016/J.ENVRES.2021.111085 43

Studies have confirmed that ferroptosis selective preferentially oxidizes specific polyphosphorylated phosphatidylethanolamine (PE)-containing polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA) and epinephrine (Kagan et al., 2017), leading to lipid peroxidation in the end, so the lipid peroxidation pathway plays the key role in regulating ferroptosis

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