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The extrinsic pathway is mediated by the interaction of FASL (Fas ligand) and FAS (Fas cell surface death receptor), which engages the adaptor molecule FADD (Fas associated via death domain) to recruit and activate CASP8 (caspase 8) [74]

It has received co-funding from the European Union's Horizon 2020 research and innovation programme under grant agreements No

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