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45 GPx4, an enzyme that specifically reduces lipid hydroperoxides, was recognized many years ago

Some pharmacological agents, such as cyclosporine A,77 dapsone78,79 and nitrofuran derivatives,80,81 also induce cholestasis due, at least in part, to their prooxidant properties

In drawing on studies that extend from clinical epidemiology, through genetics, pharmacotherapy and animal models, to cell biology and biochemistry, we have aimed to provide a comprehensible and accessible narrative, although this comes at the expense of a fully comprehensive and systematic (and inevitably longer) analysis

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Many of these patients have nerve pathology, regenerative medicine candidacy, or surgical options that have not yet been properly evaluated

doi: 10.1177/11795514241249013