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He sees one aspect as being particularly important: oxidative stress

This disorder can occur due to genetics, certain medications, or an underlying health condition

Additionally, calgranulin A, a calcium-binding S100 protein that binds calcium and belongs to the S100 protein family that regulates various intracellular processes was also increased relative to healthy controls in a serum study by Hsu et al

1e), previously shown to be a primary physiological substrate in cells 5

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DOI: 10.1016/j.bcmd.2008.02.008 27
