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vaginalis inhibited the proliferation and promoted apoptosis of PC-3 and DU145 prostate cancer cell lines cells, through up-regulation of the antiproliferative molecule p21 and down-regulation of the anti-apoptotic molecule Bcl-2 [312]

Journal of Clinical Endocrinology and Metabolism, 106(2), 388-396

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doi: 10.3389/fendo.2025.1568059 Received 28 January 2025 Accepted 10 April 2025 Published 30 April 2025 Volume 16 - 2025 Edited by Joao Dts Anselmo, Hospital do Divino Esprito Santo, Portugal Reviewed by Lucile Butruille, Musum National dHistoire Naturelle, France Updates Copyright 2025 Khudair, Khudair, Niinuma, Habib and Butler

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In triple-negative breast cancer (TNBC) cells treated with isorhamnetin (IH) and chloroquine (CQ), ROS induced Drp1-dependent mitochondrial fission and apoptosis by mediating the activation and mitochondrial translocation of CaMKII