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Immunofluorescence Formalin-fixed, paraffin-embedded tissue sections (5 m) were used for immunofluorescence

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However, only the 1A -AR subtype, when translocated to deeper endosomes, induces a sustained activation of ERK1/2, which was abrogated by -arrestin 2 knockdown or with the use of the endocytosis inhibitor concanavalin A (Perez-Aso et al., 2013

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