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Chopra S., Shankavaram U., Bylicky M., et al., Profiling mRNA, miRNA and lncRNA Expression Changes in Endothelial Cells in Response to Increasing Doses of Ionizing Radiation, Scientific Reports 12, no

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found patterning signals like Shh expression were downregulated over time while expression of synthetic genes like TGF- and insulin growth factor (IGF) were upregulated in the same developmental window, providing insights into gene families required for patterning, ECM synthesis, and maintenance of the NP

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A potential new therapeutic approach is the modulation of glutamate transporters, such as EAAT2, located on astroglial cells surrounding glutamatergic neurons to restore homeostasis by lowering extracellular glutamate concentrations [185, 186, 377]

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