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For absorption-related deficiency (pernicious anaemia, post-bariatric surgery, Crohns disease) injections are necessary because the gut cannot absorb oral B12 regardless of dose

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Shanahan MT, Tanabe H, Ouellette AJ: Strain-specific polymorphisms in Paneth cell -defensins of C57BL/6 mice and evidence of vestigial myeloid -defensin pseudogenes

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