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This molecule, known as divertin, blocks MLCK1-mediated phosphorylation of perijunctional MLC, thereby preventing subsequent occludin endocytosis and increases in leak pathway permeability 141

10.1038/nature05859 149 YangJ.HuS.BianY.YaoJ.WangD.LiuX.et al (2021b)

With the prospective overlap of key events between the two stressors, this connection may be the beginning of an AOP web

For each cardiovascular outcome, people who had had an event of the same subtype prior to baseline (based on self-reported information) were excluded from the analysis, resulting in different subsamples for each outcome (see electronic supplementary material [ESM] Fig

The most important thing is consistency