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Recent epidemiological and experimental studies have demonstrated that children born from mothers who are exposed to infections or are addicted to alcohol or drugs have a higher risk of neuronal disorders and abnormal behaviors (Jacobsen et al., 2006

Growth hormone/JAK-STAT axis signal-transduction defect: a novel treatable cause of growth failure

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Additionally, metal ion chelators, developed based on this hypothesis, need to overcome challenges such as adverse events and poor blood-brain barrier (BBB) permeability to demonstrate their potential therapeutic value

10.1038/35102186 166 TakahashiY.KondoK.HiroseT.NakagawaH.TsuyuguchiM.HashimotoM.et al