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Description
MGO non-enzymatically reacts with glutathione (GSH) to form a hemithioacetal, which is subsequently recognized by glyoxalase 1 (GLO1, lactoylglutathione lyase

Emerging pieces of evidence have suggested that miRNAs are deregulated in almost all human cancers, and found to involve in a wide spectrum of cancer hallmarks, such as sustained proliferative signaling, evasion of growth suppressors, activated invasion and metastasis, replicative immortality, angiogenesis, resistance to cell death, and evasion of immune destruction (Van Roosbroeck and Calin, 2017)

Markakis I, Alexiou E, Xifaras M, Gekas G, Rombos A

10.1038/nrc.2016.138 130 ParkS

E.SarkarK

Biochemistry 38(42):1378713794 Dekker LV, Parker PJ (1997) Regulated binding of the protein kinase C substrate GAP-43 to the V0/C2 region of protein kinase C-delta
