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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis via the salvage pathway, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis, fat oxidation, and metabolic flexibility [3]

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While increased bruising is expected with blood thinners, a sudden change in bruising pattern may indicate that anticoagulation levels have become excessive

Increased NNMT expression has also been reported in muscle-wasting conditions such as Duchenne Muscular Dystrophy (DMD)