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Accordingly, B12-induced downregulation of CCL3 strongly and negatively correlated with the hypermethylation of CpGs in its regulatory regions

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Therefore, the overall effect of ROS on the host depends on the context

This is valuable information for formulation optimization

doi:10.1155/2012/434971, PMID: 22745639 Velu CS, Niture SK, Doneanu CE, Pattabiraman N, Srivenugopal KS (2007) Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress

The disease is not genetically acquired, and the depigmentation occurs only when there is a persistent exposure or contact with the causative agent