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Interestingly, the tumor suppressor p53 is a crucial metabolic regulator that inhibits glycolysis and drives a metabolic switch towards oxidative phosphorylation in cancer cells

A transition from humid, freshwater, oxic to semiarid-induced brackish, suboxic conditions is revealed, characterized by increasing salinity, depth, and reducibility, particularly during the deposition of the Xiaganchaigou Formation

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These modalities differ in their effectiveness and invasiveness, with dietary changes gaining more interest due to their minimal risks compared to other modalities