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Contrasting these studies, nhr-80 mutants exhibit an increased stearic acid to oleic acid ratio, yet a normal lifespan (Brock et al., fat-5 , -6 , or -7 single mutants do not show a shortened life span, albeit these mutants upregulate other desaturases, perhaps in a compensatory fashion (Brock et al., fat-4 mutants exhibit an increased lifespan (Lucanic et al., 2011), possibly through their effects on N -acylethanolamine (NAE) levels and endocannabinnoid signaling (see below)

2007 Jun;137(6):1436-41

However, in a clinically unwell (unhappy) cat, even a mild to moderate BHB elevation warrants careful evaluation for DKA

Med Hypotheses (1992) 38(2):10610
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41,42 Lactate transport is mediated by proton-coupled monocarboxylate transporters (MCTs), encoded by the SLC16A gene family and comprising 14 transmembrane protein isoforms, among which MCT1 and MCT4 are functionally predominant
