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2020;(January)

Remarkably, 19S and 20S proteasome subunits are highly susceptible to carbonylation and HNE modification, suppressing their proteolytic activities (52)

Coordinates have been deposited to the PDB with accession codes 9EXG, 9EX5, 9EXF, 9EXT and 9EYT

Ethical approval The study protocol was approved by the Institute Ethics committee For Post Graduate Research of All India Institute of Medical Sciences (AIIMS), New Delhi (vide letter number IECPG-74/23.01.2019)

Medications that can alleviate symptomatic manifestations, including new levodopa formulations, dopamine agonists with different dopamine receptor stimulation profiles or modes of administration, and gene and cell transplantation therapies, are under investigation

Thus, accumulated evidence indicates that prebiotic carbohydrates can be beneficial to restrain de progression of AD