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showed that metastasis-associated fibroblasts (MAF) expressed high levels of CD38 and activated macrophages into a pro-tumoral M2-like macrophage [52]
Phase 2 trials demonstrated 10.6% mean body weight reduction at 24 weeks on 0.5mg daily tesofensine versus 2% placebo, with most effect attributed to reduced caloric intake rather than increased thermogenesis
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