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The folic acid analog methotrexate is an example of a drug that can be rendered ineffective by all of these mechanisms (Fig

FT or DHT (or other synthetic anabolic steroid) binds to a cytoplasmic AR, dissociates from heat shock proteins, and the complex translocates to the nucleus to bind to specific androgen response elements on DNA

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Plasma concentrations fall from approximately 200 ng/ml at age 20 to around 80 ng/ml by age 60
Glycopeptide Drugs: A Pharmacological Dimension Between Small Molecules and Biologics