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This suggests the important role of Tpx1 as a driving force for large H 2 O 2 gradients, which is further supported by the gradient of 42 12 ( n = 5) observed in the strain trx1 under aerobic conditions for H 2 O 2 extracellular concentrations between 2 and 50 M (Additional file 2: Figure S2a and Additional file 3: Figure S3a), in which Tpx1 recycling is compromised [33]

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The use of D2B strategies in the development of PROTACs has increased in recent years, particularly in the pharmaceutical industry

No side effects including weight loss was observed (Mansouri et al., 2021)

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