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Procedural intricacies, such as cryoprobe size and choice of cryogenic agent, contribute to tailored treatment outcomes [9,10,11]

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Xue XC, et al

Alternative Therapies in Health and Medicine , 2025

Furthermore, GPx1-deficient hearts had decreased cardiac contractility and worse diastolic dysfunction in response to doxorubicin compared to wild type hearts [43]

However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]