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Obesity-linked PPAR Ser273 phosphorylation promotes beneficial effects on the liver, despite reduced insulin sensitivity in mice

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Overall, our findings reveal that KRAS-mutant LUAD cells are vulnerable to SLC7A11 inhibition, offering potential therapeutic approaches for this currently incurable disease

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The study reported DNMT1 inhibition and depletion of SAM levels at doses, which had minimal effect on cell proliferation

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