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With weekly supplementation, for people who do not consume dietary B12 (vegans), and ovo-lacto vegetarians or people who consume very little animal-based food

Natural water sources like springs and wells often have slightly alkaline pH levels due to the presence of minerals like calcium and magnesium

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However, anecdotal reports and underground clinical use have established a standardized two-phase approach : a loading phase followed by a maintenance phase

10.1016/S0166-2236(96)80018-X Trends Neurosci