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Funding: The work was supported by the Spanish Ministry of Science and Innovation, grant number BFU2005/230 and CIBERER and grant form Generalitat Valenciana number AP-004/07

The tetanus shot is typically given to adults combined with diphtheria and pertussis, referred to as Tdap

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Chondrocytes, more specifically, produce cytokines that promote autocrine effects, inducing synthesis of catabolic enzymes and inflammatory mediators, for instance 73 According to reports, inflammatory cytokines interleukin-1 beta (IL-1) and tumor necrosis factor-alpha (TNF-) disrupt cartilage homeostasis and promote degenerative alterations due to the catabolic effects of secreted matrix metalloproteinases (MMPs) which digest cartilage matrix