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Subsequent conditional or global knockout models have identified cooperative oncogenic alterations and solidified the granule cell progenitor (GCP) lineage as the cell of origin, with GCP identity being essential for SHH-driven tumorigenesis (123)

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After oral administration, imidipide is mainly absorbed in the small intestine and enters the blood circulation system

Physiological significance of the rhythmic secretion of hypothalamic and pituitary hormones
Nat Rev Drug Discov 2013;12:730 397CohenDLTownsendRR

Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
